中山大学近五年科研发展报告
中山大学（简称：中大；英语：Sun Yat-sen University*，缩写为SYSU是中国大陆一所综合性研究型大学，位于广东省广州市、珠海市和[深圳市，直属于中华人民共和国教育部，由教育部与广东省人民政府共建。
该校前身为孙中山先生于1924年创立的国立广东大学，1926年为纪念创始人孙中山先生改称国立中山大学。1952年全国院系调整，原国立中山大学被拆分，众多院系被析出独立建校或并入他校，余下院系与私立岭南大学、华南联合大学等院校的部分院系合并，去除“国立”称谓仅称中山大学，并将校址迁至原岭南大学的校园康乐园。2001年，中山大学与曾经析出的中山医科大学合并，成为现在的中山大学。
中山大学是一流大学建设A类高校和原985工程、原211工程重点建设大学，中国著名高校之一，具有人文、社会科学、医科、理科、工科多学科厚实基础，被誉为“华南第一学府”。在2018年世界大学学术排名中，中山大学位列中国大陆第4-7名，世界第101-150名；在2019年泰晤士高等教育世界大学排名和2018年U.S.NEWS美国与世界大学排名中，位列中国大陆第8名，并分别位列世界第301-350名与237名；在2019年QS中国大陆大学排名中，中山大学位列第8名。
我们总结了近五年中山大学的科研文章发表趋势以及国自然发展趋势，并统计如下所示
SCI数量
总影响因子
平均影响因子
高水平研究文章数目（影响因子大于10）
高水平研究文章比例（影响因子大于10）
一区和二区研究文章数目（中科院分区，以最高分区为准）
一区和二区研究文章比例（中科院分区，以最高分区为准）
OA文章数目
OA文章比例
2015年-2019年各年发文量最多的杂志以及发表在此杂志的数量
2015年
2016年
2017年
2018年
2019年
2015年-2019年中山大学国自然数目
2019年高水平文章简介
Reduced Graphene Oxide Nanohybrid-Assembled Microneedles as Mini-Invasive Electrodes for Real-Time Transdermal Biosensing.( Jin, Quanchang;SMALL;IF=10.856)
A Metal-Organic Supramolecular Box as a Universal Reservoir of UV, WL, and NIR Light for Long-Persistent Luminescence.( Wang, Zheng;ANGEW CHEM INT ED ENGL;IF=12.257)
Genome-wide profiling of adenine base editor specificity by EndoV-seq.( Liang, Puping;NAT COMMUN;IF=11.878)
Asymmetric Counter-Anion-Directed Aminomethylation: Synthesis of Chiral beta-Amino Acids via Trapping of an Enol Intermediate.( Kang, Zhenghui;J AM CHEM SOC;IF=14.695)
Resonance Coupling in Heterostructures Composed of Silicon Nanosphere and Monolayer WS2: A Magnetic-Dipole-Mediated Energy Transfer Process.( Wang, Hao;ACS NANO;IF=13.903)
Generation of hepatobiliary organoids from human induced pluripotent stem cells.( Wu, Fenfang;J HEPATOL;IF=18.946)
PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA.( Tan, Liping;MOL CANCER;IF=10.679)
Pan-cancer genomic analyses reveal prognostic and immunogenic features of the tumor melatonergic microenvironment across 14 solid cancer types.( Lv, Jia-Wei;J PINEAL RES;IF=15.221)
Catalysis through Dynamic Spacer Installation of Multivariate Functionalities in Metal-Organic Frameworks.( Cao, Chen-Chen;J AM CHEM SOC;IF=14.695)
Pd films on soft substrates: a visual, high-contrast and low-cost optical hydrogen sensor.( She, Xiaoyi;LIGHT SCI APPL;IF=14)
Flexible Zn-Ion Batteries: Recent Progresses and Challenges.( Yu, Peng;SMALL;IF=10.856)
Solution-Processed Anatase Titania Nanowires: From Hyperbranched Design to Optoelectronic Applications.( Wu, Wu-Qiang;ACC CHEM RES;IF=21.661)
The relationship between autophagy and the immune system and its applications for tumor immunotherapy.( Jiang, Guan-Min;MOL CANCER;IF=10.679)
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.( Guo, Jianping;NAT CELL BIOL;IF=17.728)
Myopenia is associated with joint damage in rheumatoid arthritis: a cross-sectional study.( Lin, Jian-Zi;J CACHEXIA SARCOPENIA MUSCLE;IF=10.754)
Plasma Cell Polarization to the Immunoglobulin G Phenotype in Hepatocellular Carcinomas Involves Epigenetic Alterations and Promotes Hepatoma Progression in Mice.( Wei, Yuan;GASTROENTEROLOGY;IF=19.233)
Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation.( Kim, Jinchul;CANCER CELL;IF=23.916)
Alternative conformation induced by substrate binding for Arabidopsis thalianaN6-methyl-AMP deaminase.( Jia, Qian;NUCLEIC ACIDS RES;IF=11.147)
Challenges in anticancer drug R&D in China.( Zhao, Shen;LANCET ONCOL;IF=35.386)
Tuned Cationic Dendronized Polymer: Molecular Scavenger for Rheumatoid Arthritis Treatment.( Peng, Bo;ANGEW CHEM INT ED ENGL;IF=12.257)
Development and Validation of a Novel Diagnostic Nomogram to Differentiate Between Intestinal Tuberculosis and Crohn's Disease: A 6-year Prospective Multicenter Study.( He, Yao;AM J GASTROENTEROL;IF=10.241)
Metabolic Pathways Fueling the Endothelial Cell Drive.( Li, Xuri;ANNU REV PHYSIOL;IF=17.902)
circKIF4A acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer.( Tang, Hailin;MOL CANCER;IF=10.679)
A Plasmon-Mediated Electron Emission Process.( Shen, Yan;ACS NANO;IF=13.903)
Niobium-Based Oxides Toward Advanced Electrochemical Energy Storage: Recent Advances and Challenges.( Deng, Qinglin;SMALL;IF=10.856)
Degrading proteins in animals: "PROTAC"tion goes in vivo.( Guo, Jianping;CELL RES;IF=17.848)
MET mutation causes muscular dysplasia and arthrogryposis.( Zhou, Hang;EMBO MOL MED;IF=10.624)
Sporotrichosis.( Qin, Jinglin;N ENGL J MED;IF=70.67)
A silicon-on-insulator slab for topological valley transport.( He, Xin-Tao;NAT COMMUN;IF=11.878)
Observation of parity-time symmetry breaking transitions in a dissipative Floquet system of ultracold atoms.( Li, Jiaming;NAT COMMUN;IF=11.878)
A Highly Red-Emissive Lead-Free Indium-Based Perovskite Single Crystal for Sensitive Water Detection.( Zhou, Lei;ANGEW CHEM INT ED ENGL;IF=12.257)
Surgical Tumor-Derived Personalized Photothermal Vaccine Formulation for Cancer Immunotherapy.( Ye, Xinyu;ACS NANO;IF=13.903)
TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1/beta-catenin degradation and is targeted for GSK3B/GSK3beta-mediated phosphorylation and degradation.( Wu, Hua;AUTOPHAGY;IF=11.059)
3D Hierarchical Nanorod@Nanobowl Array Photoanode with a Tunable Light-Trapping Cutoff and Bottom-Selective Field Enhancement for Efficient Solar Water Splitting.( Tang, Songtao;SMALL;IF=10.856)
Injectable Slippery Lubricant-Coated Spiky Microparticles with Persistent and Exceptional Biofouling-Resistance.( Yang, Chengduan;ACS CENT SCI;IF=12.837)
All-in-One Porous Polymer Adsorbents with Excellent Environmental Chemosensory Responsivity, Visual Detectivity, Superfast Adsorption, and Easy Regeneration.( Xie, Yiming;ADV MATER;IF=25.809)
Ultrathin Black Phosphorus-on-Nitrogen Doped Graphene for Efficient Overall Water Splitting: Dual Modulation Roles of Directional Interfacial Charge Transfer.( Yuan, Zhongke;J AM CHEM SOC;IF=14.695)
Reply to Z. McCaw and L-J. Wei.( Li, Jibin;J CLIN ONCOL;IF=28.245)
Emerging porous materials in confined spaces: from chromatographic applications to flow chemistry.( Zhang, Jianyong;CHEM SOC REV;IF=40.443)
Weak Regulation of Many Targets Is Cumulatively Powerful-A Reply to Seitz on microRNA Functionality.( Zhao, Yixin;MOL BIOL EVOL;IF=14.797)
Lnc-UCID Promotes G1/S Transition and Hepatoma Growth by Preventing DHX9-Mediated CDK6 Down-regulation.( Wang, Yun-Long;HEPATOLOGY;IF=14.971)
Short-Term Exposure to Ambient Air Pollution and Asthma Mortality.( Liu, Yuewei;AM J RESPIR CRIT CARE MED;IF=16.494)
Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial.( He, Mingguang;LANCET;IF=59.102)
Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data.( Yuan, Tanwei;LANCET GLOB HEALTH;IF=15.873)
Predictive value of single-nucleotide polymorphism signature for recurrence in localised renal cell carcinoma: a retrospective analysis and multicentre validation study.( Wei, Jin-Huan;LANCET ONCOL;IF=35.386)
Synergistic MicroRNA Therapy in Liver Fibrotic Rat Using MRI-Visible Nanocarrier Targeting Hepatic Stellate Cells.( Wu, Jun;ADV SCI (WEINH);IF=15.804)
Robust Photodynamic Therapy Using 5-ALA-Incorporated Nanocomplexes Cures Metastatic Melanoma through Priming of CD4(+)CD8(+) Double Positive T Cells.( Li, Zhi;ADV SCI (WEINH);IF=15.804)
Enantioselective Synthesis of C-N Axially Chiral N-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C-H Activation.( Li, Honghe;ANGEW CHEM INT ED ENGL;IF=12.257)
Supercooling Behavior and Dipole-Glass-like Relaxation in a Three-Dimensional Water Framework.( Huang, Rui-Kang;J AM CHEM SOC;IF=14.695)
Two-dimensional molecular brush-functionalized porous bilayer composite separators toward ultrastable high-current density lithium metal anodes.( Li, Chuanfa;NAT COMMUN;IF=11.878)
Tumorigenesis as the Paradigm of Quasi-neutral Molecular Evolution.( Chen, Bingjie;MOL BIOL EVOL;IF=14.797)
Selective Aerobic Oxidation of a Metal-Organic Framework Boosts Thermodynamic and Kinetic Propylene/Propane Selectivity.( Wang, Yu;ANGEW CHEM INT ED ENGL;IF=12.257)
Bifacial Contact Junction Engineering for High-Performance Perovskite Solar Cells with Efficiency Exceeding 21.( Wu, Wu-Qiang;SMALL;IF=10.856)
Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinoma.( Xu, L X;ANN ONCOL;IF=14.196)
Combined Surgery and Extensive Intraoperative Peritoneal Lavage vs Surgery Alone for Treatment of Locally Advanced Gastric Cancer: The SEIPLUS Randomized Clinical Trial.( Guo, Jing;JAMA SURG;IF=10.668)
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3.( Niu, Yi;MOL CANCER;IF=10.679)
Peptide-Based Autophagic Gene and Cisplatin Co-delivery Systems Enable Improved Chemotherapy Resistance.( Lin, Yao-Xin;NANO LETT;IF=12.279)
Extracellular vesicle-packaged HIF-1alpha-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells.( Chen, Fei;NAT CELL BIOL;IF=17.728)
Interfacial Electronic Structure Modulation of NiTe Nanoarrays with NiS Nanodots Facilitates Electrocatalytic Oxygen Evolution.( Xue, Ziqian;ADV MATER;IF=25.809)
Directional Fano Resonance in an Individual GaAs Nanospheroid.( Ma, Churong;SMALL;IF=10.856)
A Rare Case of Liver Tumor.( Zhuang, Bo-Wen;GASTROENTEROLOGY;IF=19.233)
Pursuing Specific Chemotherapy of Orthotopic Breast Cancer with Lung Metastasis from Docking Nanoparticles Driven by Bioinspired Exosomes.( Xiong, Fei;NANO LETT;IF=12.279)
m(6)A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1.( Wu, Yingmin;MOL CANCER;IF=10.679)
Analysis of Ultrahigh Apparent Mobility in Oxide Field-Effect Transistors.( Chen, Changdong;ADV SCI (WEINH);IF=15.804)
A solid-state source of strongly entangled photon pairs with high brightness and indistinguishability.( Liu, Jin;NAT NANOTECHNOL;IF=33.407)
Lay health supporters aided by mobile text messaging to improve adherence, symptoms, and functioning among people with schizophrenia in a resource-poor community in rural China (LEAN): A randomized controlled trial.( Xu, Dong Roman;PLOS MED;IF=11.048)
Excessive miR-25-3p maturation via N(6)-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression.( Zhang, Jialiang;NAT COMMUN;IF=11.878)
One-Step Construction of Hydrophobic MOFs@COFs Core-Shell Composites for Heterogeneous Selective Catalysis.( Cai, Mengke;ADV SCI (WEINH);IF=15.804)
Layer-by-Layer Assembly of Three-Dimensional Optical Functional Nanostructures.( Zheng, Chaoqun;ACS NANO;IF=13.903)
Translation of the circular RNA circbeta-catenin promotes liver cancer cell growth through activation of the Wnt pathway.( Liang, Wei-Cheng;GENOME BIOL;IF=14.028)
Sustained Release of Two Bioactive Factors from Supramolecular Hydrogel Promotes Periodontal Bone Regeneration.( Tan, Jiali;ACS NANO;IF=13.903)
RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail.( Lin, Xinyao;NAT COMMUN;IF=11.878)
Genome-wide identification of mRNA 5-methylcytosine in mammals.( Huang, Tao;NAT STRUCT MOL BIOL;IF=12.109)
EMT/CSC Inhibitory Nanomedicine for In Vivo Treatment and Monitoring of HCC.( Guo, Ruomi;ADV SCI (WEINH);IF=15.804)
LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I.( Xian, Huifang;AUTOPHAGY;IF=11.059)
Lossless Fast Drop Self-Transport on Anisotropic Omniphobic Surfaces: Origin and Elimination of Microscopic Liquid Residue.( Huang, Shilin;ADV MATER;IF=25.809)
Sorafenib Plus Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin vs Sorafenib Alone for Hepatocellular Carcinoma With Portal Vein Invasion: A Randomized Clinical Trial.( He, MinKe;JAMA ONCOL;IF=22.416)
Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma.( Chen, Dong-Ping;J HEPATOL;IF=18.946)
MED12 exerts an emerging role in actin-mediated cytokinesis via LIMK2/cofilin pathway in NSCLC.( Xu, Meng;MOL CANCER;IF=10.679)
Tactile UV- and Solar-Light Multi-Sensing Rechargeable Batteries with Smart Self-Conditioned Charge and Discharge.( Fang, Zhengsong;ANGEW CHEM INT ED ENGL;IF=12.257)
Molecular Evolution in Large Steps-Codon Substitutions under Positive Selection.( Chen, Qingjian;MOL BIOL EVOL;IF=14.797)
Nanostructured High-Performance Thin-Film Transistors and Phototransistors Fabricated by a High-Yield and Versatile Near-Field Nanolithography Strategy.( Huang, Kairong;ACS NANO;IF=13.903)
1274 Engineering banana endosphere microbiome to improve Fusarium wilt resistance in banana.( Liu, Yupei;MICROBIOME;IF=10.465)
Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis.( Dong, Wei;MOL CANCER;IF=10.679)
Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation.( Tu, Jie;NAT CHEM BIOL;IF=12.154)
NOD-like receptor family, pyrin domain containing 3 (NLRP3) contributes to inflammation, pyroptosis, and mucin production in human airway epithelium on rhinovirus infection.( Liu, Tao;J ALLERGY CLIN IMMUNOL;IF=14.11)
The local immune landscape determines tumor PD-L1 heterogeneity and sensitivity to therapy.( Wei, Yuan;J CLIN INVEST;IF=12.282)
Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy.( Chen, Hong-Tao;MOL CANCER;IF=10.679)
A mid-infrared biaxial hyperbolic van der Waals crystal.( Zheng, Zebo;SCI ADV;IF=12.804)
MTNR1B loss promotes chordoma recurrence by abrogating melatonin-mediated beta-catenin signaling repression.( Liu, Lei;J PINEAL RES;IF=15.221)
Core-Shell Distinct Nanodrug Showing On-Demand Sequential Drug Release To Act on Multiple Cell Types for Synergistic Anticancer Therapy.( Huang, Jinsheng;ACS NANO;IF=13.903)
White-Light Emission from Dual-Way Photon Energy Conversion in a Dye-Encapsulated Metal-Organic Framework.( Wang, Zheng;ANGEW CHEM INT ED ENGL;IF=12.257)
Tumor Necrosis Factor Receptor-Associated Factor 6 Promotes Hepatocarcinogenesis by Interacting With Histone Deacetylase 3 to Enhance c-Myc Gene Expression and Protein Stability.( Wu, Hua;HEPATOLOGY;IF=14.971)
Phosphanyl Cyanophosphide Salts: Versatile PCN Building Blocks.( Li, Zhongshu;ANGEW CHEM INT ED ENGL;IF=12.257)
Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis.( Si, Meijun;SCI TRANSL MED;IF=17.161)
1501 Nasopharyngeal carcinoma.( Chen, Yu-Pei;LANCET;IF=59.102)
Tunable Control of Interlayer Excitons in WS2/MoS2 Heterostructures via Strong Coupling with Enhanced Mie Resonances.( Yan, Jiahao;ADV SCI (WEINH);IF=15.804)
Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes.( Luo, Zhenhua;MOL CANCER;IF=10.679)
Association of Serum Retinol-Binding Protein 4 Levels and the Risk of Incident Type 2 Diabetes in Subjects With Prediabetes.( Fan, Jiahua;DIABETES CARE;IF=15.27)
Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma.( Xu, Miao;NAT GENET;IF=25.455)
A novel AR translational regulator lncRNA LBCS inhibits castration resistance of prostate cancer.( Gu, Peng;MOL CANCER;IF=10.679)
Self-Assembled Columnar Triazole Quartets: An Example of Synergistic Hydrogen-Bonding/Anion-pi Interactions.( Zheng, Shao-Ping;ANGEW CHEM INT ED ENGL;IF=12.257)
Multifunctional low-temperature photothermal nanodrug with in vivo clearance, ROS-Scavenging and anti-inflammatory abilities.( Yang, Gang-Gang;BIOMATERIALS;IF=10.273)
METTL3 facilitates tumor progression via an m(6)A-IGF2BP2-dependent mechanism in colorectal carcinoma.( Li, Ting;MOL CANCER;IF=10.679)
Long-Lived Room-Temperature Phosphorescence for Visual and Quantitative Detection of Oxygen.( Zhou, Yusheng;ANGEW CHEM INT ED ENGL;IF=12.257)
Safety, efficacy and tumor mutational burden as a biomarker of overall survival benefit in chemo-refractory gastric cancer treated with toripalimab, a PD-1 antibody in phase Ib/II clinical trial NCT02915432.( Wang, F;ANN ONCOL;IF=14.196)
A Flexible Microsupercapacitor with Integral Photocatalytic Fuel Cell for Self-Charging.( Qiu, Meijia;ACS NANO;IF=13.903)
The origin, diversification and adaptation of a major mangrove clade (Rhizophoreae) revealed by whole-genome sequencing.( Xu, Shaohua;NATL SCI REV;IF=13.222)
On the low reproducibility of cancer studies.( Wen, Haijun;NATL SCI REV;IF=13.222)
Speciation with gene flow via cycles of isolation and migration: insights from multiple mangrove taxa.( He, Ziwen;NATL SCI REV;IF=13.222)
（注：2019年全年数据为前六个月数据估算而来，所下载的数据库为wos，且只下载第一作者和第一单位为中山大学的sci，若有遗漏，欢迎指正。）
