天然产物宝库再现中药单体羌活醇被报道可治疗类风湿关节炎啦！

    大家好，我是小燕同学，今天为大家介绍一篇关于中药天然产物羌活醇治疗RA的文章，题目为“The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis”，该文由中国科学院王红艳研究员团队及王拥军教授团队联合在2020年9月15日发表于Cell Reports，JCR分区：Q1，IF=8.105.

       类风湿关节炎(RA)是一种慢性自身免疫性疾病，主要影响关节，导致疼痛、肿胀和不可逆转的畸形。开发口服有效的小分子药物来治疗风湿性关节炎一直受到学者关注。在这篇文章中，作者主要阐述了中药单体羌活醇为JAK2/3的抑制剂，及其治疗类风湿关节炎(RA)的作用机制。

研究思路

·Intraperitoneal or Oral Administration of Notopterol Protects Both DBA/1J and C57/BL6 Mice from Collagen-Induced Arthritis

·Notopterol Inhibits Production of Multiple Pro-inflammatory Cytokines and Chemokines inTNF-a and Lipopolysaccharides (LPS)-Treated Macrophages

·Notopterol Inhibits JAK-STAT Activation to Attenuate Inflammation

·Notopterol Directly Binds JAK2 and JAK3 to Block LPS/IFN-γ and TNF-a-Induced Inflammation

·Notopterol Binds to the 932/980/981 Sites in the Kinase Domain of JAK2

·Combinationof Notopterol with TNF Blocker (Etanercept) Enhances Therapeutic Efficacy in CIA Mice

调控机制