EMT——http://dx.doi.org/10.1016/j

2020-09-29  本文已影响0人  找兔子的小萝卜

It is therefore not surprising that more recent work points to a greater flexibility in this transitional process, and cells are no longer thought to oscillate between the full epithelial and full mesenchymal states, but rather, they move through a spectrum of intermediary phases。(细胞不再被认为在完整的上皮状态和完整的间充质状态之间振荡,而是通过一系列中间阶段)
This purported plasticity means that cells could linger in intermediary stages and that they may frequently undergo a partial EMT program。(这种所谓的可塑性意味着细胞可以停留在中间阶段,并且它们可能经常经历部分EMT程序)

A partial EMT state has been noted in association with many developmental, wound healing, fibrosis, and cancer processes evident through the existence of intermediate hybrid epithelial and mesenchymal phenotypes

从上皮标志物,E-cad,间质标志物N-cad,vimentin等还有snail等来评判EMT是把EMT简单化了,在许多疾病中,比如创伤愈合,纤维化,癌症进程中的EMT叫partial EMT,也就是说部分EMT,而处在混合表型的细胞明显存在,而这种表型细胞的存在使得EMT变得更加灵活动态

Even when a mesenchymal trait is gained, there is still much heterogeneity in terms of the mesenchymal characteristic induced. In an analysis of 43 ovarian cancer cell lines, only 50% of cells with an intermediate phenotype (co-expressing cytokeratin and vimentin) induced N-cadherin.

Reconciling the Role of EMT in Fibrosis

上一篇下一篇

猜你喜欢

热点阅读