scRNA-seq的表达矩阵待解决的发育生物学问题

不同细胞类型有绝对界限吗？决定不同细胞类型的基因有定数吗？或者说是基因集？细胞分化过程的时空动态变化细节？

五大问题：

(1) Are there distinct clusters of cells within the general cell population (corresponding to either a variety of differentiation stages or to various, fully-differentiated, celltypes)?
(2) Which genes characterize each cell population?
(3) Which gene modules regulate differentiation?
(4) How do cells progress through the differentiation process?
(5) How is the differentiation process spatially reflected in the relevant tissue?

详情请点击：https://mp.weixin.qq.com/s/xFCQpsCMrBV0XlC3wQTa6A