The Point：

Background

Hi‑C provides a true all‑by‑all genome-wide interaction map, but the resolution of this map depends on the depth of sequencing. When several hundred million read pairs are obtained, as is currently routine, chromatin interactions in the mouse or human genome can be detected at 100 kb resolution.

A Quick View of TAD

The topological domains we identified are well conserved between mice and humans. This indicates that the sequence elements and mechanisms that are responsible for  stablishing higher order structures in the genome may be relatively ancient in evolution

TAD’s role in diseases

Calling TAD

Hidden Markov Model，HMM

建模：

Domaincall software

http://chromosome.sdsc.edu/mouse/hi-c/download.html

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