RCS结果解释(接上期)
目前见过的结果解释主要有两种:
1.按照曲线类型解释(针对整体而言)
对应上面的英文解释(图左男,右女)Total iron and nonheme iron intake was associated with diabetes risk, following a reverse J-shaped curve in men and an L-shaped curve in women
2.关注趋势性检验的P值(针对整体而言,曲线类型基本一致)
Multivariable-adjusted restricted cubic spline analyses suggested “J-shaped” associations of glycemic markers with CVD, cancer, and all-cause mortality. We found evidence of nonlinear associations of FPG and HbA1c with CVD, cancer, and all-cause mortality. The analyses also suggested significant nonlinear relationships between 2h-PG and both CVD and all-cause mortality, but not cancer. Evidence indicated a significant linear relationship between 2h-PG and cancer (P <0.001)
3.分段解释(更为具体)
文中有写到median前后是接近线性才用per SDIn figure 1, we used restricted cubic splines toflexibly model and visualize the relation of predictedfat mass and lean body mass with all cause mortalityin men. The risk of all cause mortality was relativelyflat until around 21 kg of predicted fat mass andthen started to increase rapidly afterwards (P for non-linearity <0.001). The average BMI for men with21 kg of predicted fat mass was 25. Above 21 kg, thehazard ratio per standard deviation higher predictedfat mass was 1.22 (1.18 to 1.26). Regarding the strongU shaped relation between predicted lean body massand all cause mortality, the plot showed a substantialreduction of the risk within the lower range of predictedlean body mass, which reached the lowest risk around56 kg and then increased thereafter (P for non-linearity<0.001). Below 56 kg, the hazard ratio per standard deviation higher predicted lean body mass was 0.87 (0.82 to 0.92).
总体而言,结果解释都是仁者见仁,智者见智
RCS的内容基本就是这三期内容,觉得有帮助可以点个赞,谢谢啦~