时间序列单细胞转录组数据分析
2019-04-23 本文已影响46人
因地制宜的生信达人
文章是: Reconstruction of developmental landscapes by optimal-transport analysis of single-cell gene expression sheds light on cellular reprogramming.
虽然于2017年9月公布在了bioRxiv上面，但是至今仍然没正式发表，包含了六万多个单细胞转录组数据，持续追踪了MEF细胞系诱导为IPSC细胞的动态变化过程，并且从发育的角度分析了这些数据。
We demonstrate the power of WADDINGTON-OT by applying the approach to study 65,781 scRNA-seq profiles collected at 10 time points over 16 days during reprogramming of fibroblasts to iPSCs.
详情请点击：https://mp.weixin.qq.com/s/r-Isbqs1sxysJCLghmj-JA
