RI-1

"目录号: HY-15317

Cell Cycle/DNA Damage-

RI-1是RAD51抑制剂，IC50在5到30 μM之间。

RAD51

相关产品

T0070907-RI-2-RAD51 Inhibitor B02-

生物活性

Description

RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.IC50 Value: 5-30 μMTarget: RAD51in vitro: RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 μM range. RI-1 decreases the rejoining of γ-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation. in vivo:

References

[1].dke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP.  RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.  Nucleic Acids Res. 2012 May 9.