The pluripotent state in mouse and human | Development | The Company of Biologists

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摘要

In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture equivalent of the late epiblast in the pre-implantation embryo, with which they share a unique defining set of features. Recent studies have focused on the identification and propagation of a similar cell state in human. Although the capture of an exact human equivalent of the mouse naïve PSC remains an elusive goal, comparative studies spurred on by this quest are lighting the path to a deeper understanding of pluripotent state regulation in early mammalian development.
在小鼠中，naive多能干细胞 (PSC) 被认为代表了植入前胚胎中晚期上胚层的细胞培养等效物，它们共享一组独特的定义特征。最近的研究集中在人类相似细胞状态的识别和传播上。尽管捕获与小鼠naive PSC 的精确人类等效物仍然是一个难以捉摸的目标，但由这一探索引发的比较研究正在为更深入地了解早期哺乳动物发育中的多能状态调控开辟道路。

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笔记