神经系统marker (Nature Neuroscience,
2022-05-10 本文已影响0人
小熊_wh
文章：A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex
PMID: 30349106
文章中针对神经元、少突胶质细胞、星形胶质细胞、小胶质细胞、内皮细胞分别给了marker，个人觉得最主要是的神经元没有区分兴奋性和抑制性神经元，直接用ENO2基因作为神经元的marker了。
## Nat Neurosci markers
genelist=c('ENO2', # neurons
'OLIG2', # oligodendrocytes
'GFAP', # astrocytes
'CD68', # microglia
'CD34' # endothelial cells)
看看NCBI里面关于ENO2的描述：'This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]'
