co-localization analyses
2018-12-17 本文已影响56人
又是一只小菜鸟
参考文献：co-localization analyses (Giambartolomei et al., 2014; Pickrell et al., 2016)
这个方法是用来干什么的？
a natural question to ask is whether two independent association signals at the same locus, typically generated by two GWAS studies, are consistent with a shared causal variant. If the answer is positive, we refer to this situation as colocalised traits, and the probability that both traits share a causal mechanism is greatly increased.
A main application of our method is the systematic comparison between a new GWAS dataset and a large catalogue of association studies in order to identify novel shared mechanisms.
https://github.com/chr1swallace/coloc
