Ranirestat

"目录号: HY-15314

Metabolic Enzyme/Protease-

Ranirestat (AS-3201)是醛糖还原酶抑制剂，糖尿病性神经病变临床3期。

Aldose Reductase

相关产品

Isoliquiritigenin-Epalrestat-Tolrestat-Aldose reductase-IN-1-Alrestatin-IMIRESTAT-RISARESTAT-

生物活性

Description

Ranirestat (AS-3201) is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy.

Clinical Trial

NCT00101426

Sumitomo Dainippon Pharma Co., Ltd.

Diabetic Neuropathy

October 2004

Phase 3

NCT00101426

Sumitomo Dainippon Pharma Co., Ltd.

Diabetic Neuropathy

October 2004

Phase 3

NCT00927914

Eisai Inc.

Mild to Moderate Diabetic Sensorimotor Polyneuropathy.

July 2009

Phase 2-Phase 3

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References

[1].Kurono M, et al. Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: a significant role of specific binding by serum albumin in the improved potency and stability. Biochem Pharmacol. 2006 Jan 12;7

[2].Matsumoto T, et al. Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux. J Pharmacol Sci. 2009 Feb;109(2):203-10.

[3].Toyoda F, et al. Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats. J Diabetes Res. 2014;2014:672590.